简历
姓名:邱振鹏
出生年月:198707
学历/学位:博士研究生
职称:教授
邮箱:qiuz@hbucm.edu.cn
教育经历:
2011/09 — 2014/12 武汉大学基础医学院,基础医学,博士
2009/09 — 2011/06 武汉大学8188www威尼斯,中药学,硕博连读转博
2005/09 — 2009/06 中南民族大学8188www威尼斯,药学,学士
工作经历:
2023/04-至今 湖北中医药大学8188www威尼斯,教授,博士生导师
2021/01 — 2023/03 湖北中医药大学8188www威尼斯,副教授,博士生导师
2019/12 — 2020/12 明尼苏达大学医学院,访问学者
2018/09 — 2023/03 湖北中医药大学8188www威尼斯,副教授,硕士生导师
2017/06 — 2018/08 湖北中医药大学8188www威尼斯,讲师,硕士生导师
2015/07 — 2017/05 湖北中医药大学8188www威尼斯,讲师
教学与科学研究:
研究领域:(1)分子药理学;(2)天然药物药效学与毒理学研究;(3)中药药理学
研究兴趣:(1)慢性肝脏疾病(NAFLD、NASH、NAFLD-HCC)发生机制与药物干预研究;(2)基于脂肪酸代谢重编程的代谢相关疾病防治策略研究
讲授课程:(1)本科生课程:《药理学》、《中药药理学》;(2)研究生课程:博士研究生《分子药理学》(课程负责人)
博士研究生招生方向:
中药学(学术学位,招生代码:100800)
硕士研究生招生方向:
药理学(学术学位,招生代码:100706;专业学位招生代码:105500)
主持/参与主要科研项目:
1. 国家自然科学基金面上项目,2025/01-2028/12,主持;
2. 国家自然科学基金面上项目,2021/01-2024/12,主持;
3. 国家自然科学基金青年科学基金项目,2017/01-2019/12,主持;
4. 湖北省自然科学基金面上项目,2022/06-2024/06,主持;
5. 湖北省自然科学基金面上项目,2017/01-2018/12,主持;
6. 湖北省教育厅科研计划项目,2016/01-2018/12,主持;
7. 湖北省技术创新专项(重大项目),2017/01-2020/12,技术骨干;
8. 国家自然科学基金青年科学基金项目,2017/01-2019/12,技术骨干。
学术团体兼职与同行评议:
1. 中华中医药学会中药实验药理分会,委员;
2. 湖北省药理学会,理事;
3. 湖北省毒理学会,理事;
4. 湖北省药理学会中药药理专业委员会,委员;
5. 湖北省药学会药物经济学专业委员会,委员;
6. 武汉药学会老年药学专业委员会,委员;
7. 国家自然科学基金面上项目/青年科学基金通讯评审专家(2019/2020/2021/2022/2024);
8. 湖北省社发领域省级技术创新项目会议评审专家(2024)
已发表的部分研究成果:
1. Haixiang Cheng, Yuan Yang, Junjie Hu, Liang Chen, Ming Yuan, Hongzhi Du, Ziqiang Xu, ZHENPENG QIU. Cyclic adenosine 3’, 5’-monophosphate (cAMP) signaling is a crucial therapeutic target for ulcerative colitis[J]. Life Sciences. 2024; 353, 122901. (中科院2区Top期刊,JCR: Q1,共同通讯作者,Last author)
2. Cong Zhang, Qiao Tong, Kexin Liu, Tongyun Mao, Yingying Song, Yaqin Qu, Xin Chen, ZHENPENG QIU. Morroniside delays the progression of non-alcoholic steatohepatitis by promoting AMPK-mediated lipophagy[J]. Phytomedicine. 2024; 129, 155703. (中科院1区Top期刊,JCR: Q1,共同通讯作者,Last author)
3. Jun Yang, Xiaolei Tang, Liang Chen, Junjie Hu, Shan Li, Ming Yuan, Xianxiang Tian, ZHENPENG QIU. Liver-derived Exosomal miRNA in NAFLD: Mechanisms of Action, Biomarkers, and Therapeutic Applications[J]. Current Medicinal Chemistry. 2024. (SCI,JCR: Q2,共同通讯作者,Last author)
4. Yan Meng, Cheng Hu, Jingjing Cheng, Wenxiu Qiu, Qi Wang, Xinyan Chen, Cong Chang, Junjie Hu, ZHENPENG QIU, Guohua Zheng. The extraction, structure characterization and hydrogel construction of a water-insoluble β-glucan from Poria cocos[J]. Carbohydrate Research. 2023; 534, 108960. (SCI,JCR: Q2,共同通讯作者)
5. Jiawei Liu, Xinyu Huang, Fengxian Zhang, Xueting Luo, Wenqian Yu, Cao Li, ZHENPENG QIU, Yi Liu, Ziqiang Xu. Metal-free multifunctional nanozymes mimicking endogenous antioxidant system for acute kidney injury alleviation[J]. Chemical Engineering Journal. 2023; 477, 147048. (中科院1区Top期刊,JCR: Q1,共同通讯作者)
6. Yuan Yang, Jia Xu, Jie Tu, Yi Sun, Cong Zhang, ZHENPENG QIU, Han Xiao. Polygonum cuspidatum Sieb. et Zucc. Extracts improve sepsis-associated acute kidney injury by inhibiting NF-κB-mediated inflammation and pyroptosis[J]. Journal of Ethnopharmacology. 2024; 319, 117101. (中科院2区Top期刊,JCR: Q1,共同通讯作者)
7. Peng Cao, Yi Wang, Cong Zhang, Mitchell A. Sullivan, Wen Chen, Xiang Jing, Huifan Yu, Fei Li, Qu Wang, Zhongshi Zhou, Qi Wang, Wen Tian, ZHENPENG QIU, Lianxiang Luo. Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy[J]. Journal of Nutritional Biochemistry. 2023; 120, 109414. (中科院2区期刊,JCR: Q1,共同通讯作者)
8. Haimin Li, Xinyu Huang, Fengxian Zhang, Xueting Luo, Wenqian Yu, Cao Li, Bingbing Jiang, ZHENPENG QIU, Ziqiang Xu. Specific discrimination of zinc and manganese ions by label free dual emissive carbon dots by ratio-metric mode[J]. Talanta. 2023; 260, 124627. (中科院1区Top期刊,JCR: Q1,共同通讯作者)
9. Yuzhen Lu, Junjie Hu, Liang Chen, Shan Li, Ming Yuan, Xianxiang Tian, Peng Cao, ZHENPENG QIU. Ferroptosis as an emerging therapeutic target in liver diseases[J]. Frontiers in Pharmacology. 2023; 14. (中科院2区期刊,JCR: Q1,共同通讯作者,Last author)
10. Cong Zhang, Yingying Song, Ming Yuan, Liang Chen, Qianyu Zhang, Junjie Hu, Yan Meng, Shan Li, Guohua Zheng, ZHENPENG QIU. Ellagitannins-Derived Intestinal Microbial Metabolite Urolithin A Ameliorates Fructose-Driven Hepatosteatosis by Suppressing Hepatic Lipid Metabolic Reprogramming and Inducing Lipophagy[J]. Journal of Agricultural and Food Chemistry. 2023; 71(9), 3967-3980. (中科院1区Top期刊,JCR: Q1,共同通讯作者,Last author)
11. Yuzhen Lu, Cong Zhang, Yingying Song, Liang Chen, Xin Chen, Guohua Zheng, Yuan Yang, Peng Cao, ZHENPENG QIU. Gallic acid impairs fructose-driven de novo lipogenesis and ameliorates hepatic steatosis via AMPK-dependent suppression of SREBP-1/ACC/FASN cascade[J]. European Journal of Pharmacology. 2023; 940, 175457. (SCI,JCR: Q1,共同通讯作者,Last author)
12. Xiangyun Tan, Xinyu Huang, Zhuhang Lu, Liang Chen, Junjie Hu, Xianxiang Tian, ZHENPENG QIU. The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease[J]. Frontiers in Pharmacology. 2023; 14. (中科院2区期刊,JCR: Q1,共同通讯作者,Last author)
13. Xiangyun Tan, Yi Sun, Liang Chen, Junjie Hu, Yan Meng, Ming Yuan, Qi Wang, Shan Li, Guohua Zheng, ZHENPENG QIU. Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation[J]. Journal of Agricultural and Food Chemistry. 2022; 70(20), 6108-6122. (中科院1区Top期刊,JCR: Q1,共同通讯作者,Last author)
14. Haimin Li, Qianyu Zhang, Xueting Luo, Zhihao Yao, Yaqin Qu, Erjing Wang, Bingbing Jiang, ZHENPENG QIU, Cao Li, Ziqiang Xu. Intrinsic dual emissive carbon dots for ratiometric sensing of acetylcholinesterase fluctuation induced by organophosphorus pesticide intoxication[J]. Sensors and Actuators B: Chemical. 2022; 373, 132590. (中科院1区Top期刊,JCR: Q1,共同通讯作者)
15. Wei Guo, Lianxiang Luo, Yan Meng, Wen Chen, Lixiu Yu, Cong Zhang, ZHENPENG QIU, Peng Cao. Luteolin alleviates methionine–choline-deficient diet-induced non-alcoholic steatohepatitis by modulating host serum metabolome and gut microbiome[J]. Frontiers in Nutrition. 2022; 9. (中科院2区期刊,JCR: Q2,共同通讯作者)
16. Cong Zhang, Yingying Song, Liang Chen, Peng Chen, Ming Yuan, Yan Meng, Qi Wang, Guohua Zheng, ZHENPENG QIU. Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy[J]. Frontiers in Pharmacology. 2022; 13. (中科院2区期刊,JCR: Q1,共同通讯作者,Last author)
17. Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, ZHENPENG QIU. Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway[J]. Journal of Cellular and Molecular Medicine. 2022; 26(14), 3995-4006. (中科院2区期刊,JCR: Q2,共同通讯作者,Last author)
18. Shengfu Yi, Cong Zhang, Junjie Hu, Yan Meng, Liang Chen, Huifan Yu, Shan Li, Guihong Wang, Guohua Zheng, ZHENPENG QIU. Preparation, Characterization, and In Vitro Pharmacodynamics and Pharmacokinetics Evaluation of PEGylated Urolithin A Liposomes[J]. AAPS PharmSciTech. 2021; 22(1), 26. (SCI,共同通讯作者,Last author)
19. Cong Zhang, Lei Sheng, Ming Yuan, Junjie Hu, Yan Meng, Yong Wu, Liang Chen, Huifan Yu, Shan Li, Guohua Zheng, ZHENPENG QIU. Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met[J]. Toxicology and Applied Pharmacology. 2020; 392, 114918. (SCI,JCR: Q2,共同通讯作者,Last author)
20. Cong Zhang, Junjie Hu, Lei Sheng, Ming Yuan, Yong Wu, Liang Chen, Guihong Wang, ZHENPENG QIU. Ellagic acid ameliorates AKT-driven hepatic steatosis in mice by suppressing de novo lipogenesis via the AKT/SREBP-1/FASN pathway[J]. Food & Function. 2019; 10(6), 3410-3420. (中科院1区Top期刊,JCR: Q1,通讯作者,Last author)
21. ZHENPENG QIU, Cong Zhang, Junxuan Zhou, Junjie Hu, Lei Sheng, Xin Li, Liang Chen, Xiang Li, Xukun Deng, Guohua Zheng. Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade[J]. Molecular Carcinogenesis. 2019; 58(1), 31-41. (中科院2区期刊,JCR: Q2,共同第一/通讯作者)
22. Cong Zhang, Junjie Hu, Lei Sheng, Ming Yuan, Yong Wu, Liang Chen, Guohua Zheng, ZHENPENG QIU. Metformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation[J]. Toxicology and Applied Pharmacology. 2019; 365, 51-60. (SCI,JCR: Q2,共同通讯作者,Last author)
23. Cong Zhang, Junxuan Zhou, Junjie Hu, Sheng Lei, Ming Yuan, Liang Chen, Guihong Wang, ZHENPENG QIU. Celecoxib attenuates hepatocellular proliferative capacity during hepatocarcinogenesis by modulating a PTEN/NF-κB/PRL-3 pathway[J]. RSC Advances. 2019; 9(36), 20624-20632. (SCI,JCR: Q2,共同通讯作者,Last author)
24. Junjie Hu, Xin Li, Junxuan Zhou, Cong Zhang, Guohua Zheng, ZHENPENG QIU. Celastrol delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma model via suppressing fatty acid synthase expression and AKT/ERK phosphorylation[J]. RSC Advances. 2018; 8(25), 13976-13983. (SCI,JCR: Q2,共同通讯作者,Last author)
25. Junxuan Zhou, Cong Zhang, Guo-Hua Zheng, ZHENPENG QIU. Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A[J]. Evidence-based Complementary and Alternative Medicine. 2018; 8478943. (SCI,共同通讯作者,Last author)
26. Benhong Zhou, Jing Wang, Guohua Zheng, ZHENPENG QIU. Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21[J]. Food and Chemical Toxicology. 2016; 97, 375-384. (中科院2区期刊,JCR: Q1,通讯作者,Last author)
27. Lingli Zhang, Yi Tu, Wen He, Yan Peng, ZHENPENG QIU. A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation[J]. European Journal of Pharmacology. 2015; 762, 55-62. (SCI,JCR: Q2,共同通讯作者,Last author)
28. Benhong Zhou, Huilan Yi, Jun Tan, Yue Wu, Gang Liu, ZHENPENG QIU. Anti-proliferative effects of polyphenols from pomegranate rind (Punica granatum L.) on EJ bladder cancer cells via regulation of p53/miR-34a axis[J]. Phytotherapy Research. 2015; 29(3), 415-422. (SCI,JCR:Q1,通讯作者,Last author)
29. ZHENPENG QIU, Benhong Zhou, Long Jin, Honglian Yu, Lijuan Liu, Youyi Liu, Chengchen Qin, Shuixiang Xie, Fan Zhu. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells[J]. Food and Chemical Toxicology. 2013; 59, 428-437. (中科院2区Top期刊,JCR: Q1,共同第一作者)
指导本科生、研究生获奖:
1. 鲁谕蓁等,2023年全国第十八届“挑战杯”大学生课外学术科技作品竞赛,三等奖;
2. 鲁谕蓁等,2023年湖北省第十四届“挑战杯”大学生课外学术科技作品竞赛,特等奖;
3. 孙懿等,2021年湖北省第十三届“挑战杯”大学生课外学术科技作品竞赛,二等奖;
4. 张聪等,2018年湖北省大学生创业大赛创业计划竞赛,铜奖。
(更新于2024年9月)